Volume 45 - Article 33 | Pages 1011–1040
A world apart: Levels and determinants of excess mortality due to COVID-19 in care homes: The case of the Belgian region of Wallonia during the spring 2020 wave
By Olivier J. Hardy, Dominique Dubourg, Mélanie Bourguignon, Simon Dellicour, Thierry Eggerickx, Marius Gilbert, Jean-Paul Sanderson, Aline Scohy, Eline Vandael, Jean-Michel Decroly
References
Armitage, R. and Nellums, L. B. (2020). COVID-19 and the consequences of isolating the elderly. The Lancet Public Health 5(5): 256.
Arons, M.M., Hatfield, K.M., Reddy, S.C., Kimball, A., James, A., Jacobs, J.R., Taylor, J., Spicer, K., Bardossy, A.C., Oakley, L.P., Tanwar, S., Dyal, J.W., Harney, J., Chisty, Z., Bell, J.M., Methner, M., Paul, P., Carlson, C.M., McLaughlin, H.P., and Public Health–Seattle and King County and CDC COVID-19 Investigation Team (2020). Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. The New England Journal of Medicine 382(22): 2081–2090.
Ars, P., Dal, L., and Poulain, M. (1988). Comment appréhender le problème statistique des petits nombres en démographie? In: Les migrations internationales (Actes du colloque de l’AIDELF de Calabre. : 156–170.
Belmin, J., Um-Din, N., Donadio, C., Magri, M., Nghiem, Q.D., Oquendo, B., Pariel, S., and Lafuente-Lafuente, C. (2020). Coronavirus disease 2019 outcomes in French nursing homes that implemented staff confinement with residents. JAMA Network Open 3(8): 2017533–2017533.
Bustos Sierra, N., Bossuyt, N., Braeye, T., Leroy, M., Moyersoen, I., Peeters, I., Scohy, A., Heyden, J., Van Oyen, H., and Renard, F. (2020). All-cause mortality supports the COVID-19 mortality in Belgium and comparison with major fatal events of the last century. Archives of Public Health 78(1): 117.
Comas-Herrera, A., Ashcroft, E., and Lorenz-Dant, K. (2020). International examples of measures to prevent and manage COVID-19 outbreaks in residential care and nursing home settings. Report in LTCcovid.org, International Long-Term Care Policy Network, CPEC-LSE.
Comas-Herrera, A., Zalakaín, J., Litwin, C., Hsu, A.T., Lemmon, E., Henderson, D., and Fernández, J.L. (2020). Mortality associated with COVID-19 outbreaks in care homes: early international evidence. Article in LTCcovid.org, International Long-Term Care Policy Network, CPEC-LSE.
Dolejs, J. (2015). Age trajectories of mortality from all diseases in five countries of Central Europe during the last decades. Biodemography and Social Biology 61(1): 40–64.
Dudel, C., Riffe, T., Acosta, E., Raalte, A., Strozza, C., and Myrskylä, M. (2020). Monitoring trends and differences in COVID-19 case-fatality rates using decomposition methods: Contributions of age structure and age-specific fatality. PLOS ONE 15(9): 0238904.
ECDC Public Health Emergency Team, Danis, K., Fonteneau, L., Georges, S., Daniau, C., Bernard-Stoecklin, S., Domegan, L., O’Donnell, J., Hauge, S.H., Dequeker, S., Vandael, E., Heyden, J., Renard, F., Sierra, N.B., Ricchizzi, E., Schweickert, B., Schmidt, N., Abu Sin, M., Eckmanns, T., Paiva, J.A., and Schneider, E. (2020). High impact of COVID-19 in long-term care facilities, suggestion for monitoring in the EU/EEA, May 2020. Eurosurveillance 25(22): pii=2000956.
Eckerle, I. and Meyer, B. (2020). SARS-CoV-2 seroprevalence in COVID-19 hotspots. The Lancet 396(10250): 514–515.
Einiö, E., Guilbault, C., Martikainen, P., and Poulain, M. (2012). Gender differences in care home use among older Finns and Belgians. Population 67(1): 71–95.
Falconer, M. and O’Neill, D. (2007). Profiling disability within nursing homes: a census-based approach. Age and Ageing 36(2): 209–213.
Fisman, D.N., Bogoch, I., Lapointe-Shaw, L., McCready, J., and Tuite, A.R. (2020). Risk factors associated with mortality among residents with Coronavirus disease 2019 (COVID-19) in long-term care facilities in Ontario, Canada. JAMA Network Open 3(7): 2015957–2015957.
Gompertz, B. (1825). XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F.R.S.&c. Philosophical Transactions of the Royal Society of London 115: 513–583.
Herm, A., Poulain, M., and Anson, J. (2014). Excess mortality risks in institutions: The influence of health and disability status. In: Anson, J. and Luy, M. (eds.). Mortality in an international perspective. Cham: Springer: 245–263.
Herzog, S., Bie, J.D., Abrams, S., Wouters, I., Ekinci, E., Patteet, L., Coppens, A., Spiegeleer, S.D., Beutels, P., Damme, P.V., Hens, N., and Theeten, H. (2020). Seroprevalence of IgG antibodies against SARS coronavirus 2 in Belgium: A prospective cross-sectional study of residual samples. MedRxiv.
Hewitt, J., Carter, B., Vilches-Moraga, A., Quinn, T. J., Braude, P., Verduri, A., Pearce, L., Stechman, M., Short, R., Price, A., Collins, J.T., Bruce, E., Einarsson, A., Rickard, F., Mitchell, E., Holloway, M., Hesford, J., Barlow-Pay, F., Clini, E., and Guaraldi, G. (2020). The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study. The Lancet Public Health 5(8): 444–451.
Horiuchi, S., Finch, C.E., Meslé, F., and Vallin, J. (2003). Differential patterns of age-related mortality increase in middle age and old age. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58(6): 495–507.
Hoxha, A., Wyndham-Thomas, C., Klamer, S., Dubourg, D., Vermeulen, M., Hammami, N., and Cornelissen, L. (2020). Asymptomatic SARS-CoV-2 infection in Belgian long-term care facilities. The Lancet Infectious Diseases 21(4): e67.
Humblet, P. (2020). Inégalités sociales de santé: Tout a changé? Politique 112: 99–102.
Imaizumi, Y. (1996). Longitudinal analysis of mortality from breast cancer in Japan, 1950–1993: Fitting Gompertz and Weibull functions. Mechanisms of Ageing and Development 88(3): 169–183.
Keiding, N. and Clayton, D. (2014). Standardization and control for confounding in observational studies: A historical perspective. Statistical Science 29(4): 529–558.
Ladhani, S.N., Chow, J.Y., Janarthanan, R., Fok, J., Crawley-Boevey, E., Vusirikala, A., Fernandez, E., Perez, M.S., Tang, S., Dun-Campbell, K., Evans, E.W., Bell, A., Patel, B., Amin-Chowdhury, Z., Aiano, F., Paranthaman, K., Ma, T., Saavedra-Campos, M., Myers, R., and Ramsay, M. E. (2020). Increased risk of SARS-CoV-2 infection in staff working across different care homes: Enhanced CoVID-19 outbreak investigations in London care homes. The Journal of Infection 81(4): 621–624.
Laferrère, A., Heede, A., Bosch, K., and Geerts, J. (2013). entry into institutional care: predictors and alternatives. In: Börsch-Supan, A., Brandt, M., Litwin, H., and Weber, G. (eds.). Active ageing and solidarity between generations in Europe: First results from SHARE after the economic crisis. Berlin: DeGruyter: 253–264.
Logar, S. (2020). Care home facilities as new COVID-19 hotspots: Lombardy Region (Italy) case study. Archives of Gerontology and Geriatrics 89(SI COVID-19): 104087.
Medford, A. and Trias-Llimós, S. (2020). Population age structure only partially explains the large number of COVID-19 deaths at the oldest ages. Demographic Research 43(19): 533–544.
Miettinen, O.S. (1972). Components of the crude risk ratio. American Journal of Epidemiology 96(2): 168–172.
Molenberghs, G., Faes, C., Aerts, J., Theeten, H., Devleesschauwer, B., Bustos Sierra, N., Braeye, T., Renard, F., Herzog, S., Lusyne, P., Heyden, J., Van Oyen, H., Van Damme, P., and Hens, N. (2020). Belgian COVID-19 mortality, excess deaths, number of deaths per million, and infection fatality rates. MedRxiv.
Nepomuceno, M.R., Acosta, E., Alburez-Gutierrez, D., Aburto, J.M., Gagnon, A., and Turra, C.M. (2020). Besides population age structure, health and other demographic factors can contribute to understanding the COVID-19 burden. Proceedings of the National Academy of Sciences 117(25): 13881–13883.
Petretto, D.R. and Pili, R. (2020). Ageing and COVID-19: What is the role for elderly people? Geriatrics 5(2): 25.
Quigley, D.D., Dick, A., Agarwal, M., Jones, K.M., Mody, L., and Stone, P.W. (2020). COVID‐19 preparedness in nursing homes in the midst of the pandemic. Journal of the American Geriatrics Society 68(6): 1164–1166.
Rada, A.G. (2020). Covid-19: The precarious position of Spain’s nursing homes. BMJ 369: 1586.
Ricklefs, R.E. and Scheuerlein, A. (2002). Biological implications of the Weibull and Gompertz models of aging. Journals of Gerontology – Series A Biological Sciences and Medical Sciences 57(2): 69–76.
Riggs, J.E. (1991). Longitudinal Gompertzian analysis of ischemic heart disease mortality in the US, 1962–1986: A method of demonstrating the deterministic dynamics describing its decline. Mechanisms of Ageing and Development 57(1): 1–14.
Sciensano (2020). COVID-19 Bulletin Epidémiologique Hebdomadaire du 19 juin 2020. Brussels: Sciensano.
Szczerbińska, K. (2020). Could we have done better with COVID-19 in nursing homes? European Geriatric Medicine 11: 639–643.
Trabucchi, M. and De Leo, D. (2020). Nursing homes or besieged castles: COVID-19 in Northern Italy. The Lancet Psychiatry 7(5): 387–388.
Van Beckhoven, D., Duysburgh, E., Montourcy, M., De Rouck, M., Vilain, A., Catteau, L., Deblonde, J., Wyndham-Thomas, C., and Van Goethem, N. (2020). Points clés de la surveillance des patients hospitalisés atteints d’une infection COVID-19 confirmée: Résultats jusqu’au 14 juin 2020.
Verbeek, H., Gerritsen, D.L., Backhaus, R., Boer, B.S., Koopmans, R.T., and Hamers, J.P. (2020). Allowing visitors back in the nursing home during the COVID-19 crisis: A Dutch national study into first experiences and impact on well-being. Journal of the American Medical Directors Association 21(7): 900–904.
Verity, R., Okell, L.C., Dorigatti, I., Winskill, P., Whittaker, C., Imai, N., Cuomo-Dannenburg, G., Thompson, H., Walker, P.G.T., Fu, H., Dighe, A., Griffin, J.T., Baguelin, M., Bhatia, S., Boonyasiri, A., Cori, A., Cucunubá, Z., FitzJohn, R., Gaythorpe, K., and Ferguson, N.M. (2020). Estimates of the severity of coronavirus disease 2019: A model-based analysis. The Lancet Infectious Diseases 20(6): 669–677.
Wenham, C., Smith, J., and Morgan, R. (2020). COVID-19: The gendered impacts of the outbreak. The Lancet 395(10227): 846–848.
Williamson, E.J., Walker, A.J., Bhaskaran, K., Bacon, S., Bates, C., Morton, C.E., Curtis, H.J., Mehrkar, A., Evans, D., Inglesby, P., Cockburn, J., McDonald, H.I., MacKenna, B., Tomlinson, L., Douglas, I.J., Rentsch, C.T., Mathur, R., Wong, A.Y.S., Grieve, R., and Goldacre, B. (2020). Factors associated with COVID-19-related death using OpenSAFELY. Nature 584(7821): 430–436.
Wu, J., McCann, A., Katz, J., and Peltier, E. (2020). 153,000 missing deaths: Tracking the true toll of the Coronavirus outbreak.